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In high performance liquid chromatography (HPLC), the selection of an appropriate mode of detection is vital to the success of any separation. To this end, there are numerous choices one might consider when configuring a new HPLC setup. Mass spectrometry (MS) is an alternative method of detection and identification that is much more robust than UV. Here, we describe how the VERITY 1920 Mass Spectrometer allows for MS detection capabilities at an affordable price for HPLC fraction collection.